No proteins were exclusive of CIS or LH, whereas potentially secreted Alb, Col3a1, Lyz2, Serpinc1 were present only in CTRL, and potentially secreted Col6a3, Col18a1, Htra1, Prss35, Igfbp5, Eef1a1, Isoc1, Tagln2, Tpi1, Pgam1 proteins were found exclusively in CIS + LH. Here, HTRA1 is linked to in situ carcinoma.