Only one potentially secreted (Atp5a1) protein appeared exclusively in CTRL, while six new proteins were detected only in CIS (secreted Colec12, Adam12, Agt, Fbn1, Atox1, and Rplp2), four in LH (secreted Ltbp1, Col1a2f, Grn, Col5a1), and six in CIS + LH (Cstb, Tuba1c, Uchl1, Nme1 and Ldhp). The gene discussed is ADAM12; the disease is in situ carcinoma.