Moreover, collagenic Col5a11 was found in LH and CIS only, at higher amounts in the latter, implying induction by both compounds and reciprocal inhibition; Ctsb, belonging to the peptidase C1 family and usually favoring autophagy and apoptosis, was present only in CIS and CIS + LH, suggesting induction by the drug and no effect of LH. The gene discussed is PLOD1; the disease is in situ carcinoma.