Among proteins only in LH at 12 h, Ltbp1, belonging to the family of TGF-β binding proteins, collagenic Colla2f, and Grn, an endoplasmic reticulum stress-responsive factor, appeared in the other groups at 24 h, denoting a relatively early induction by LH, delayed by CIS, and also occurring over time in CTRL and CIS + LH. The gene discussed is GRN; the disease is in situ carcinoma.