The possible meaning of the trends of Isoc1 (appearing in CTRL and LH at this time and transiently present in CIS + LH at 2 h, never found in CIS alone), Htra1 (appearing in CTRL but already present in LH at 12 h and accumulated in CIS + LH throughout the culture, never found in CIS alone), Atp5a1 (coming out in LH and CIS + LH but present in CTRL at 12 h, never found in CIS alone) and Fbn1 (present in CTRL, LH, and CIS, already at 12 h, in CIS, but never found in CIS + LH) was discussed above. Here, HTRA1 is linked to in situ carcinoma.