Secreted Ctgf, a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins, Dkk3, an antagonist of the canonical WNT signaling but with a role also in cytoskeleton organization, and Serping1, a highly glycosylated Serpin family G member involved in the regulation of the complement cascade, were shared by CTRL, LH, and CIS but absent in CIS + LH, implying a combined inhibitory effect of the compounds somehow beneficial for the cultured ovarian tissue. This evidence concerns the gene DKK3 and in situ carcinoma.