PLOD1 and in situ carcinoma: Although compounds released in the extracellular milieu at relatively low concentrations which might be able to exert these effects and may have been missed by our analysis (KL itself was not detected in our assay), the present results provide useful indications about a number of pro- and anti-apoptotic molecules or pathways that LH is able to stimulate in the ovarian tissues, likely of the somatic compartment, upon CIS exposure.