Secreted Colec12, a scavenger receptor, Atox1, a copper metal-chaperone protein, and the ribosomal protein Rplp2, found initially only in CIS, appeared in all other groups at 24 h, entailing initial induction by the drug but an unimportant role in the maintenance of the cultured ovarian tissues. Here, ATOX1 is linked to in situ carcinoma.