Hbb-b2 remained stable in CIS + LH, variable in CIS or LH at later culture times, and appeared in CTRL at 24 h; Igf2 and Hist1h1b appeared at 12 h in CTRL and thereafter remained basically stable in all groups, suggesting, for all these proteins, functions mostly independent from the presence of the drug and hormone. The gene discussed is PLOD1; the disease is in situ carcinoma.