At the same time, CIS appeared to increase the release of several proteins that generally favor apoptosis, such as Amh and the ECM protein Fbn1 reported to be able to induce this process in the follicular cells [43,49,50], the cytokine Fam3c [44], Ecm1 [36], the 14-3-3 family hub protein Ywhaz [39], and the protease Ctsb [51]. The gene discussed is ECM1; the disease is in situ carcinoma.