Only one potentially secreted (Atp5a1) protein appeared exclusively in CTRL, while six new proteins were detected only in CIS (secreted Colec12, Adam12, Agt, Fbn1, Atox1, and Rplp2), four in LH (secreted Ltbp1, Col1a2f, Grn, Col5a1), and six in CIS + LH (Cstb, Tuba1c, Uchl1, Nme1 and Ldhp). This evidence concerns the gene NME1 and in situ carcinoma.