PLOD1 and in situ carcinoma: Media from the CIS + LH group showed a higher number of proteins at 2 h in comparison to the others (CTRL = 29; LH = 25; CIS = 23; CIS + LH = 41); at 12 h, media from the LH, CIS, and CIS + LH groups contained a similar number of proteins, which was higher than CTRL (CTRL = 62; LH = 85; CIS = 92; CIS + LH = 88); at 24 h, in media from LH group, the number of proteins was slightly lower in comparison to the others (CTRL = 126; LH = 117; CIS = 128; CIS + LH = 128) (Figure 2).