Since Ltbp1, Grn, and Col5a1 have been recently been shown to favor cell survival by inhibiting various apoptotic pathways [25,26,27], we can postulate a rapid inductive effect of LH on these proteins but an effective antiapoptotic action against CIS only for Col5a1, how we will discuss below. Here, COL5A1 is linked to in situ carcinoma.