Since Ltbp1, Grn, and Col5a1 have been recently been shown to favor cell survival by inhibiting various apoptotic pathways [25,26,27], we can postulate a rapid inductive effect of LH on these proteins but an effective antiapoptotic action against CIS only for Col5a1, how we will discuss below. The gene discussed is LTBP1; the disease is in situ carcinoma.