FBN1 and in situ carcinoma: The other secreted proteins showed different courses: at 24 h, metalloprotease Adam12 also appeared in CTRL and CIS + LH, but not in LH; the member of the ovalbumin–serine proteases inhibitor family Agt also appeared in CTRL; the large ECM protein Fbn1 was found in CTRL and LH but missed in CIS + LH.