Only one potentially secreted (Atp5a1) protein appeared exclusively in CTRL, while six new proteins were detected only in CIS (secreted Colec12, Adam12, Agt, Fbn1, Atox1, and Rplp2), four in LH (secreted Ltbp1, Col1a2f, Grn, Col5a1), and six in CIS + LH (Cstb, Tuba1c, Uchl1, Nme1 and Ldhp). Here, ATP5F1A is linked to in situ carcinoma.