Among these molecules, particularly interesting were the inhibition of expression and/or release of proapoptotic factors induced by CIS, such as Amh, Fam3c, and Fbn1, and the reactivation of expression and/or release of antiapoptotic factors inhibited by CIS, such as Atp5a1, Htra1, Isoc1, Gsn, Ldha, Prdx2, and Prss23 (see above), or de novo stimulation of others, such as Calm1, Col5a1, Ctla2a, Eno1, Pkm, and, interestingly, Sod1, an isoform of a superoxide dismutase one of the major antioxidant enzymes (Figure 7, Table 1 and Table 2). The gene discussed is CALM1; the disease is in situ carcinoma.