Only one potentially secreted (Atp5a1) protein appeared exclusively in CTRL, while six new proteins were detected only in CIS (secreted Colec12, Adam12, Agt, Fbn1, Atox1, and Rplp2), four in LH (secreted Ltbp1, Col1a2f, Grn, Col5a1), and six in CIS + LH (Cstb, Tuba1c, Uchl1, Nme1 and Ldhp). Here, LTBP1 is linked to in situ carcinoma.