Finally, Hist1h1e, another histone mediating exosomal uptake (see above), was detected in CTRL, CIS, and CIS + LH but not in LH alone; it remained stable in CTRL and CIS + LH, variable in CIS, and appeared at 12 h in LH, implying an initial inhibitory action of the hormone not maintained in the presence of CIS. This evidence concerns the gene PLOD1 and in situ carcinoma.