Activated neutrophils directly interact with endothelial E- and P-selectin, expressed by the activated endothelium, and have been shown to capture sickle RBCs via αMβ2 integrin (Mac-1; CD11b) expression on the cell surface during TNFα-induced vascular inflammation in a mouse model of SCD [21,22]. This evidence concerns the gene TNF and Schnyder corneal dystrophy.