PIEZO1 and hydrops fetalis: It will be useful in the future to investigate the pathological cardiovascular effects of this mutant at an older age and under conditions of stress—e.g., transverse aortic constriction-mediated pressure overload-induced cardiac hypertrophy, fibrosis and HF—to evaluate any beneficial or deleterious effects of PIEZO1 GOF mutation on cardiac function and disease progression, as PIEZO1 appears to be a key protein involved in maintaining homeostatic functional state of the heart.