Furthermore, PIEZO1-mediated Ca2+ influx is involved in inflammatory pathways including the IL-6 receptor family and Ca2+-sensitive MAPK family such as p38 in various systems (e.g., renal fibrosis models, liver carcinoma cell lines or human dermal fibroblasts) [13,14,17,64,65,66,67]. This evidence concerns the gene MAPK14 and hepatocellular carcinoma.