Again, in this setting, colon expression of Ace2 mRNA was dissociated from inflammation, since, despite the fact exendin-3 worsened the severity of inflammation and immune dysfunction, the GLP-1-R antagonist dramatically downregulated the expression of Ace2 mRNA, as well as the expression of Gcg and Gpbar1 (Figure 6). This evidence concerns the gene GCG and immune system disorder.