ACE2 and colitis: We focused our attention on how colon ACE is regulated in response to colitis in rodent models of IBD and, as illustrated in Figure S1, we found that Ace2 mRNA was robustly upregulated in three models of colitis induced by administration of oxazolone, TNBS and DSS, confirming previous animal [35] and human data [14,34,41,42].