Therefore, based on our previous data on miR-146a dysregulation in ALS astrocytes from the mSOD1 mouse model, we decided to analyze the distribution of miR-146a in the secretome from iAstrocytes differentiated from ALS patients, which revealed alterations in its expression, i.e., ALS2, ALS3, ALS6 and ALS7. This evidence concerns the gene FUS and amyotrophic lateral sclerosis.