HMGB1 and amyotrophic lateral sclerosis: However, in the case of ALS7, the upregulation of miR-146a with its mimic reduced the gene expression level of MIK67 (encoding for Ki-67), GJA1 (encoding for Cx43) and HMGB1 in ALS7 (at least p < 0.05, Figure 5B); these results support the heterogeneous presentation and progression patterns of ALS disease.