ALS2 and amyotrophic lateral sclerosis: Therefore, based on our previous data on miR-146a dysregulation in ALS astrocytes from the mSOD1 mouse model, we decided to analyze the distribution of miR-146a in the secretome from iAstrocytes differentiated from ALS patients, which revealed alterations in its expression, i.e., ALS2, ALS3, ALS6 and ALS7.