Moreover, 8305C-derived ectosomes contained multiple other procoagulant (e.g., plasminogen activator inhibitor 1, thrombospondin-1) as well as anti-coagulant (e.g., urokinase-type plasminogen activator, tissue-type plasminogen activator) factors, indicating a more complex role of ectosomes in blood coagulation during cancer progression. Here, THBS1 is linked to cancer.