We found significant interaction patterns between time x group with significantly increased stimulated production of sIL-1RA, IL-5, CXCL-8, IL-9, IL-15, IL-17, FGF, IFN-γ, CXCL10, PDGF, CCL5, TNF-α, VGEF, and G-CSF in MDMD versus controls, while there were no significant differences between controls and simple depression. The gene discussed is IL5; the disease is major depressive disorder.