MYC and neoplasm: We have previously reported that MAD-SID expression in triple negative breast cancer cells induced differentiation in 2-D cultures, morphogenesis in 3-D cultures and exerted anti-tumor effects in SID expressing MMTV-Myc cells derived from MMTV-c-Myc tumors injected into the fat pads of syngeneic friend virus B-type (FVB) mice [21].