In cancers driven by TFEB/TFE3/MITF, expression of genes encoding endolysosomal cation channels, TRPML1, TRPML2 and TPC2, is elevated, and either the knockdown or pharmacological inhibition of these channels attenuates the growth and invasiveness of the tumors [160,226,227,247,248,249,250,251,252]. The gene discussed is TFEB; the disease is cancer.