In view of the compelling evidence showing the role of TRPM7 upregulation/hyperactivity in mediating post-ischemia neuronal death [1,2], our results correspond more with previous studies suggesting that ischemia induces more pronounced loss of PV neurons than of glutamatergic neurons [15] and provide a possible explanation for PV neuronal sensitivity, namely the more pronounced upregulation of TRPM7 following ischemia. This evidence concerns the gene TRPM7 and ischemia.