Improved performance of myocardial patches in MI was also obtained by boosting neoangiogenesis using a combined construct of a six-layered cardiomyocyte sheet and a poly(vinyl alcohol) fiber mat bearing poly(lactic-co-glycolic acid) nanoparticles that locally release vascular endothelial growth factor (VEGF) in an athymic rat model [271]. The gene discussed is VEGFA; the disease is myocardial infarction.