IL6 and breast carcinoma: In brief, in T-47D and ZR-75-1 breast carcinoma cells, the changes triggered by IL-6 comprised changes typically observed in cells undergoing epithelial to mesenchymal (fibroblastoid) transformation (EMT); these included the development of elongated cells with enhanced motility, increased cell-cell separation, decreased adherence type junctions, loss of vinculin and desmoplakin I/II, decreased actin stress fibers, perinuclear retraction of cytokeratin filament connections and cytokeratins as well as reduced cell surface E-cadherin [3,4,43,44,45,46].