TP53 and cancer: This review highlights studies of epithelial-mesenchymal transformation (EMT) produced by IL-6 in breast carcinoma cells, as well as mechanisms underlying the contribution of IL-6 to sex bias in liver cancer, the dysregulation of IL-6 promoter function in cancer cells resulting from mutations in p53, alterations in STAT3 transcriptional signaling, and the newer understanding of STAT3 nuclear bodies in the cancer cell as metastable biomolecular condensates.