IL6 and Hypoalbuminemia: This systemic IL-6 spillover is considered a basis for paraneoplastic syndrome, which includes cachexia (loss of body weight), fever, enhanced erythrocyte sedimentation rate, and altered acute phase plasma protein levels (e.g., enhanced C-reactive protein levels and hypoalbuminemia) [8,9,10,11,12,13,14,15,16,17].