The interaction between tumor cells, immune cells and CAFs involves a wide range of molecules including cytokines such as transforming growth factor beta (TGFB), interleukin-6 (IL6), C-C motif chemokine ligand 2 (CCL2), interleukin-8 (IL8), C-X-C motif chemokine ligand 1 (CXCL1) and hepatocyte growth factor (HGF) [17]. Here, CCL2 is linked to neoplasm.