CGAS and Aicardi-Goutieres syndrome: Learning from AGS and SAVI patients might teach us where, in man, the cGAS/STING pathway plays an important role: for example, prominent damage of blood vessels has been observed in SAVI patients [12], suggesting that activation of STING might play a role in some of the non-genetically linked vasculitis disorders, although evidence for the latter is still fragmentary.