Considering the relative sensitivity of PAIs to hypochlorite-induced inactivation, it is possible that PAI-2 could become the dominant inhibitor of uPA and tPA during inflammatory conditions featuring enhanced oxidative stress, such as atherosclerosis [53,54,55,56], periodontitis [57,58,59] and particularly pregnancy [35,60,61], when there is marked upregulation of PAI-2 at the placenta and in blood plasma. Here, PLAU is linked to atherosclerosis.