These results aligned with data from a previous study, which demonstrated that terminally exhausted CD8+ tumor-infiltrating lymphocytes (TILs) in a mouse melanoma model displayed a similar molecular signature, expressing high levels of Gzma, Gzmb, Klrg1, CXC3CR1, Ccl3 and Ccl4 [21]. This evidence concerns the gene CD8A and neoplasm.