Since fibroblasts express a similar genetic composition to that of neuronal cells, metabolite profiling of dermal fibroblasts of sporadic ALS has been carried out to assess the bioenergetic alterations.Gene expression of Sxc- was significantly reduced and glutathione peroxidase 6 (GPX6) was elevated in a cohort of patients characterized with hypermetabolism and trans-sulphuration pathways. The gene discussed is GPX6; the disease is amyotrophic lateral sclerosis.