Previous evidence also showed that acute toxic insults, such as Aβ (1–42) peptide, 6-hydroxy dopamine (6-OHDA) and chronic AD conditions, increases levels of eukaryotic translation initiation factor eIF2α, to combat oxidative insult through xCT upregulation and thereby maintaining glutathione pools [145]. The gene discussed is SLC7A11; the disease is Alzheimer disease.