Kamerkar et al. modified exosomes to transport siRNA or shRNA aiming KRAS in PC cells, which efficaciously blocked cancer proliferation in experimental animal models and augmented the overall survival [152], while Mendt et al. employed exosomes armed with siRNA to target KRAS G12D, which extended the survival in different PC mouse models [153]. The gene discussed is KRAS; the disease is pachyonychia congenita.