LDLR and atherosclerosis: To study the functions of macrophage PXR in atherosclerosis, we previously generated LDLR−/− mice with myeloid-specific PXR deficiency (PXRΔMyeLDLR−/−) mice by crossing PXRΔMye (LysM-Cre/PXRF/F) mice with LDLR−/− mice [45].