To determine whether DCHP affect macrophage PXR signaling to influence atherosclerosis development, 4-week-old male PXRΔMyeLDLR−/− and PXRF/FLDLR−/− littermates were treated with 10 mg/kg body weight of DCHP or vehicle control by daily oral gavage for 12 weeks. The gene discussed is NR1I2; the disease is atherosclerosis.