Under canonical pathway analysis, ‘PTEN Signaling’ (FOXO1, FOXO3, ITGA3, ITGA6, ITGB1, and ITGB4), the ‘Semaphorin Neuronal Repulsive Signaling Pathway’ (ITGA3, ITGA6, ITGB1, and ITGB4), and the ‘Systemic Lupus Erythematosus In B Cell Signaling Pathway’ (FOS, FOXO1, FOXO3, TBK1, and TNFSF10) were predicted to be significantly activated. The gene discussed is FOXO3; the disease is systemic lupus erythematosus.