Another study found higher expression of ATG5 in the lesional and perilesional skin of both active and stable vitiligo patients and it claimed that higher expressed ATG5 might induce apoptosis in the perilesional skin of active vitiligo patients by autophagy-independent functions [43], while Haiyan Yu et al. found ATG5 and ATG12, key components of autophagy formation, were significantly reduced in melanocytes of vitiligo patients under oxidative stress [44]. This evidence concerns the gene ATG12 and vitiligo.