After overlapping it with DEGs in vitiligo samples, we identified 39 DEARGs (BNIP3, TNFSF10, FOS, PEX3, RGS19, GABARAPL2, EEF2K, CASP4, CALCOCO2, ATG4C, TBK1, RAB11A, RPTOR, SPHK1, ATG2A, FOXO3, ITGA6, CAPNS1, EIF2AK3, HSPA5, ITGB1, BAG3, PPP1R15A, FOXO1, NRG2, ITGA3, CAPN2, TP73, NRG1, GABARAPL1, DAPK2, MAPK8IP1, ITGB4, TP53INP2, DAPK1, SERPINA1, GRID1, CX3CL1, and DLC1) in vitiligo lesions under the criteria of absolute log2FC > 0.58 and p-value < 0.05. The gene discussed is CASP4; the disease is vitiligo.