MBD2 and acute myeloid leukemia: T Cell Acute Lymphoblastic Leukaemia (T-ALL) and Acute Myeloid Leukaemia (AML): The role of both demethylases has been widely studied in T-ALL leukaemia, where they play opposing roles: KDM6A (UTX) acts as a tumour repressor, and mutations of KDM6A are seen dominantly in male patients, where there is a gender bias of 3:1 (male:female) in development of T-ALL (see Table 1).