The E1099K mutations: In 10% of ALL, and especially in paediatric B-ALL (B-precursor ALL), a mutation of glutamic acid to lysine occurs in the SET domain of NSD2, resulting in increased activity of the enzyme, leading to increased levels of H3K36me2 and decreased levels of H3K27 trimethylation [60,61], see Table 1. This evidence concerns the gene NSD2 and acute lymphoblastic leukemia.