Enteropathy-associated T cell lymphoma (EATL) is an aggressive, often lethal cancer, which can arise from celiac disease, and mutations in SETD2 are found in 32% of cases [57], while in clear cell renal carcinomas (ccRCC), deletions or mutations of SETD2 are also found [54,110,111]. This evidence concerns the gene SETD2 and nonpapillary renal cell carcinoma.