The use of cell lines may represent the pathogenesis state of the individual from which it was drawn; one study reported to investigate the CC 7 chemokine receptor (CCR7) in PII biopsies—they cultured primary fibroblasts grown from idiopathic pulmonary fibrosis in CB-17 mice and were able to observe that their cultures could induce interstitial fibrosis and increased hydroxyproline [33]. The gene discussed is CCR7; the disease is pulmonary fibrosis.