In eosinophils, the hallmark cell of asthma, TSLP, has been shown to prevent apoptosis; upregulate the adhesion molecule CD18; intercellular adhesion molecule-1; and induce IL-6, CXCL8, CXCL1, and CCL2, and downregulate expression of L-selectin. The gene discussed is TSLP; the disease is asthma.