Allergic asthmatic patients with late asthmatic responses (bronchoconstriction, AHR, eosinophilic airway inflammation) to inhaled allergen challenge have further elevations of IL-25 in the epithelium and submucosa, and in eosinophils and basophils post-challenge [38,45,46,87], as well as elevated IL-17RB in myeloid dendritic cells (mDCs), plasmacytoid dendritic cells (pDCs), eosinophils and their progenitors, and basophils measured in blood and sputum [45,46,47,88], thereby linking IL-25 signaling to acute worsening of asthma. The gene discussed is IL25; the disease is asthma.