CD4 and rheumatoid arthritis: In our analysis, the frequencies of active (CCR7 lowPD-1 high) and quiescent (CCR7 highPD-1 low) cTfh cells within the blood CD4+CXCR5+CD45RA- and CD8+CXCR5+ cells were not significantly different among the three study groups, though a trend (p = 0.09) was observed for active cTfh (CCR7 lowPD-1 high) in the blood of RA patients when compared to healthy controls (Figure 1D,E).