Despite the presently limited exploration of the mechanisms of the LPS-BG synergistic NETs formation in COVID-19, common downstream signaling from TLR-4 and Dectin-1—such as spleen tyrosine kinase (SYK), extracellular signal-regulated kinases (ERK), protein kinase C (PKC), and nuclear factor kappa B (NFκB)—might be responsible for the synergy [90,91,92,93,94] (Figure 7). Here, TLR4 is linked to COVID-19.