METTL3 and cardiac hypertrophy: Gao et al. [68] showed that cardiac-hypertrophy-associated PIWI-interacting RNA (CHAPIR) promotes pathological myocardial hypertrophy and cardiac remodeling by targeting METTL3-mediated m6A methylation of poly (ADP-ribose) polymerase 10 (Parp10) mRNA during transcription.