Li et al. [88] showed that liver-specific overexpression of METTL3 aggravates lipid-metabolism disorders and insulin resistance in mice administered a high-fat diet, whereas liver-specific knockout of METTL3 alleviates lipid-metabolism disorders and insulin resistance by extending the mRNA half-life of Lpin1, an important regulator of lipid metabolism. Here, METTL3 is linked to Insulin resistance.