AGTR1 and nephrosclerosis: Furthermore, signaling through both receptors has been linked to the mediation of many biological functions, such as AGTR1 mediating vasoconstriction, cell proliferation, nephrosclerosis, vascular media hypertrophy, endothelial dysfunction, inflammation, and immune responses and promoting aging; and signaling trough AGTR2 has been linked to vasodilation, development, cell differentiation, tissue repair, and apoptosis [40,41].