Utilizing human eutopic endometrial tissue from women with severe (stage III/IV) endometriosis and disease-free women, Bunch and associates [43] found that PGRMC1 and PGRMC2 transcript expression levels were significantly downregulated in the secretory phase in the eutopic endometrium in women with endometriosis. The gene discussed is PGRMC1; the disease is endometriosis.