CCND1 and lung cancer: Moreover, in a study by Zhou et al., atranorin was found to suppress β-catenin-mediated TOPFLASH activity by inhibiting the nuclear import of β-catenin and downregulating β-catenin/LEF and c-jun/AP-1 downstream target genes such as CD44, CCND1, and c-MYC in lung cancer cells [32].