LOC550643 shared miR-29b-2-5p binding elements with MEKK2, NOTCH2, and Cbl-b, implying that miR-29b-2-5p participated in LOC550643 regulated colon cancer growth and apoptosis through MEKK2, NOTCH2, and p53 signaling. The gene discussed is NOTCH2; the disease is colonic neoplasm.