To assess whether EGFR-regulated miRNAs in MSCs were involved in the cross-talk with breast cancer cells, we analyzed the levels of expression of the differentially expressed miRNAs in conditioned media from untreated and TGFα-treated MSCs, particularly focusing on miRNAs that we found to be associated with breast cancer in the OncomiR database, including miR-23c and miR-379-3p. This evidence concerns the gene EGFR and breast cancer.