The cleavage of mature E-cadherin by MMP9 releases into the extracellular environment a soluble E-cadherin (sE-cad) fragment of about 80 kDa, which localizes to the exosome surface and, by retaining its binding ability, plays an important role as a paracrine/autocrine inducer of angiogenesis and cancer cell invasion [83,84]. The gene discussed is CDH1; the disease is cancer.