The disruption of the basement membrane (BM), which consists of a dense network of crosslinked laminins and collagens, accompanied by various glycoproteins and proteoglycans, facilitates not only the spread of invading cancer cells or the influx of immune cells into the tumor stroma but also the formation of new blood and lymphatic vessels that are necessary for supplying tumor tissue with nutrients and oxygen. Here, ART4 is linked to neoplasm.