There are increasing studies reporting associations between the MMP family and cancer immunotherapy; for example, in the case of combined treatment of tumor mouse models of B16F10 melanoma and Lewis lung carcinoma with the MMP2/9 inhibitor SB-3CT and anti-programmed death receptor 1 (PD-1) or anti-cytotoxic T cell antigen 4 (CTLA-4), an enhanced antitumor immune response was observed [166]. This evidence concerns the gene MMP2 and cancer.