Similarly, MMP9-mediated processing of interleukin-2 receptor α (IL-2Rα or CD25), which plays an essential role for regulatory T cell (Treg) function, resulted in the abrogation of the efficacy of tumor-reactive cytotoxic lymphocytes by generating the soluble IL-2Rα/DC25 form that antagonized wild-type IL-2Rα [131]. The gene discussed is MMP9; the disease is neoplasm.