In this study, we identified FGF2 rs1048201, PDGFRB rs246395, PDGFRA rs2228230, MMP2 rs243865, rs7201, and TIMP2 rs7501477 as predictors of the clinical outcome in HNSCC patients receiving radiotherapy alone or combined with chemotherapy. Here, FGF2 is linked to head and neck squamous cell carcinoma.