Due to the different etiology of HPV-induced tumors, analysis was performed separately in p16-positive OPSCC and a pooled cohort containing p16-negative OPSCC and all non-oropharyngeal tumors (except for the only 5 NPC samples), in which HPV-driven malignancies are reported to represent only a small minority of less than 5% when critically assessed through detection of HPV E6/E7 mRNA in addition to p16 or HPV DNA [41,42,43,44,45,46]. Here, CDKN2A is linked to nasopharyngeal carcinoma.