This study revealed the effects of apigenin on cervical cancer cells, including inhibiting cervical cancer cell viability, inducing cell cycle arrest at the G2/M phase by modulating cyclin B1/CDK1 and p21cip1, activating mitochondrial-mediated apoptosis, and inhibiting migration and EMT of cervical cancer cells. This evidence concerns the gene CDKN1A and cervical carcinoma.