The apigenin down-regulated FAK signaling (FAK, paxillin, and integrin β1) and PI3K/AKT signaling (PI3K, AKT, and mTOR), which inactivated or activated various signaling targets, such as Bcl-2, Bax, p21cip1, CDK1, CDC25c, cyclin B1, fibronectin, N-cadherin, vimentin, laminin and E-cadherin, leading to mitochondrial-mediated apoptosis, G2/M-phase arrest, and reduction in cancer cell migration, thereby producing anticancer effects in cervical cancer. Here, CDKN1A is linked to cancer.