For example, in hereditary hemochromatosis that comprise a heterogeneous cohort of inherited iron overload diseases, particularly caused by the mutation of proteins that restrict iron absorption (homeostatic iron regulator (HFE), hemojuvelin (HJV), FPN1), excessive iron is absorbed by organs such as the heart, the intestine and the liver [63]. The gene discussed is HJV; the disease is Rare hereditary hemochromatosis.