To compensate the high oxidative stress, cancer cells tend to activate and upregulate the transcription and expression of antioxidant factors and genes, such as GPX4, SLC7A11 (Solute Carrier Family 7 Member 11) and FSP-1, which have been described as central ferroptosis regulators in the previous chapter [42,43,44]. The gene discussed is GPX4; the disease is cancer.