These five extracted lncRNAs (LUCAT1, AC099850.3, AL365203.2, AL031985.3, AC009005.1) could be linked to an HCC specific tumor microenvironment (especially dendritic cells (DCs), macrophages, mast cells, follicular helper T cells, Th1/2 cells, Th2 cells and regulatory T cells) and to the anti-cancer ability of immune checkpoint inhibitors to predict the response to immunotherapy in HCC [126]. The gene discussed is LUCAT1; the disease is hepatocellular carcinoma.