Enrichment analysis revealed that KEGG signaling pathways tightly related to carcinogenesis (such as “PI3K-Akt” [56], “MAPK” [57], “Rap1” [58], “regulation of actin cytoskeleton” [59], “focal adhesion” [60], and “proteoglycans in cancer” [61]) were the most dominantly affected ones by DNA methylation changes. The gene discussed is AKT1; the disease is cancer.