On the other hand, mutations of major driver genes, including EGFR, KRAS, TP53, and ALK are highly concordant between primary NSCLC and matched brain metastatic lesions, suggesting that early clonal genomic events during carcinogenesis of NSCLC may be involved in dissemination to the brain [116,118,128]. This evidence concerns the gene TP53 and non-small cell lung carcinoma.