Evidence for an impact of hypoxia and the transcription factors HIF-1 and -2 exists in other cell types, such as in bone marrow-derived mesenchymal stem cells where the PI3K/Akt-HIF-1α-CXCR4/CXCR7 pathway is essential for cell migration, adhesion, and survival [168] or in glioblastoma cells [191]. This evidence concerns the gene HIF1A and glioblastoma.