TLR4 and neoplasm: CXCR7, but not CXCR4, expression can be increased by lipopolysaccharide treatment in cells expressing both TLR4 and the MD2 coreceptor [221]; additionally, in patients, high expression of TLR4, MD2 and CXCR7 is associated with tumor cell infiltration in lymph nodes and distant metastases [221].