PDCD1 and colorectal carcinoma: In the exploratory NICHE study (ClinicalTrials.gov: NCT03026140), patients with early-stage MSS or MSI CRC and neoadjuvant treatment with a single dose of anti-CTLA-4 (ipilimumab) and two doses of anti-PD1 (nivolumab) led to 100% and 27% response in MSI and MMS tumors, respectively [27].