ACKR3 and colorectal carcinoma: This agrees with the in vivo experience of Guillemot et al., who showed that CXCR7 is a key factor in the progression of CRC metastases specifically in the lungs, since systemic treatment of mice with CXCR7 antagonists reduces metastasis in the lungs but not in the liver, after intravenous injection of HT-29 or C26 cells expressing CXCR7 [92].