In contrast to studies favoring a poor prognosis for high CXCR4 and CXCR7 expression in CRC, Kheirelseid et al. observe that patients with above-median expression have lower mortality (mean survival 46 months) than patients with below-median CXCR7 expression (mean survival 27 months). Here, ACKR3 is linked to colorectal carcinoma.