In these CRCs tissues, an analysis of the expression of 85 genes regulating epigenetic processes showed a loss of expression of a histone acetyltransferase, the protein P300/CBP-associated factor (PCAF), and forced expression of PCAF in colon cancer cell lines restored the expression of CXCL12 [52]. The gene discussed is KAT2B; the disease is malignant colon neoplasm.