Immunohistochemical analysis of paraffin-embedded tumor sections from NB and melanoma mice reveals that Analog-1 significantly decreased the level of Ki-67, which is a marker of cell proliferation, in comparison to control mice (NB-bearing mice Analog-1 vs. Control p < 0.001; melanoma-bearing mice Analog-1 vs. Control p < 0.05) (Figure 6c). This evidence concerns the gene MKI67 and melanoma.