CFTR and cystic fibrosis: RNF5 is also involved in the premature degradation of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel [6], and its genetic or pharmacological inhibition in vivo attenuated the defects associated to deletion of phenylalanine 508 (F508del), which is the most frequent CF mutation impairing CFTR trafficking to the cell surface [8,31] Two novel drugs targeting RNF5 have been discovered by a computational approach, based on ligand docking and virtual screening.