Although higher expressers of γ-H2AX and 53BP1 were unrelated to tumor locations, both were significantly associated with the presence of epithelioid histology (γ-H2AX: p = 0.012; 53BP1: p < 0.001), higher mitotic rates (γ-H2AX: p = 0.021; 53BP1: p < 0.001), and higher risk levels by both the NIH risk scheme (γ-H2AX: p = 0.002; 53BP1: p < 0.001) and the NCCN guidelines (both p < 0.001). Here, TP53BP1 is linked to neoplasm.