Notably, a primary gastric GIST with in-frame KIT p.V560del also harbored a missense SDHC p.T32N SNV of unknown pathogenic significance, while the amplification (CNV = 7) and gain (CNV = 4) of SDHC were detected in one wild-type GIST and two GISTs with truncated NF1, respectively. Here, SDHC is linked to gastrointestinal stromal tumor.