Any process disrupting the epithelial lining of the peritoneum has the potential to increase CA125 levels, so its elevations are observed in the presence of endometriosis, adenomyosis, ovarian and uterine fibroma, pregnancy, menstruation, liver cirrhosis, abdominal tuberculosis, heart insufficiency and non-ovarian (e.g., uterine, pulmonary, or gastrointestinal) malignancies [15,16]. This evidence concerns the gene MUC16 and cirrhosis of liver.