Interestingly, gene expression profiling of primary leukemic phase MCL cells highlights the aberrant expression of genes associated with TGFB signalling pathway activation, including downstream targets associated with resistance to FAS-mediated apoptosis (e.g., CASP8 and FADD-like apoptosis regulator (CFAR)) [81,103]. This evidence concerns the gene TGFB1 and mantle cell lymphoma.