With regard to the effect of endocannabinoid-like compounds on tumour angiogenesis, it was demonstrated using CD31 immunostaining of xenografts with B16 cells in C57BL/6 mice and tube formation assays with human umbilical vein endothelial cells (HUVEC) that PEA alone or in combination with the FAAH inhibitor URB597 leaves the neovascularisation of the xenografts and the angiogenic capacities of HUVEC virtually unchanged, although the compounds strongly inhibit xenograft growth [87]. The gene discussed is FAAH; the disease is neoplasm.