CNR1 and melanoma: For example, in A375 melanoma cells, the inverse CB1 agonist AM-251 has been associated in vitro with arrest of the G2-M cell cycle, inhibition of the expression of anti-apoptotic proteins such as B-cell lymphoma 2 (BCL2) and survivin, and increased expression of the proapoptotic Bcl-2-associated X protein (BAX) [91].