The effect of CBD on tumour angiogenesis in the context of melanoma and squamous cell carcinoma has not yet been addressed either, and reports of anti-angiogenic effects in skin cancer have been limited to a few studies reporting the anti-angiogenic properties of WIN 55,212-2 and JWH-133 [23,81] and the FAAH inhibitor URB597 [87]. The gene discussed is FAAH; the disease is melanoma.