ESR1 and breast carcinoma: Table 1b describes disease characteristics and treatment. At diagnosis, 6236 (81.1%) had invasive cancers, 4714 (61.3%) had no nodal involvement; 4957 (64.5%), 4368 (56.8%) and 1490 (19.4%) had ER-, PR- and HER2-positive tumours respectively. Other sociodemographic, medical history, breast cancer risk factors, disease and treatment characteristics that were explored can be found in Supplementary Table S1.