When pre-diagnostic PA intensity was further adjusted for pre-diagnostic PA duration, engaging in vigorous levels of pre-diagnostic PA remained significantly associated with reduced risk of invasive cancer (OR invasive vs. non-invasive (reference): 0.71 [0.58–0.88], p = 0.001) and HER2-positive tumour (OR HER2-negative vs. HER2-positive (reference): 1.31 [1.04–1.65], p = 0.015) (data not shown). Here, ERBB2 is linked to neoplasm.