ALK and non-small cell lung carcinoma: In a real-world analysis of 76 ALK+ NSCLC patients enrolled in early or expanded access programs for lorlatinib in Asia and the United States, respective ORR and median PFS for those treated with <2 previous TKIs, 2 previous TKIs and 3 previous TKIs, were 42% and NR months, 35% and 11.2 months and 18% and 6.5 months [27].