MACC1 and digestive system cancer: Meanwhile, MACC1 has been established by us and many groups as a key player, and prognostic and predictive biomarker for tumor progression and metastasis in more than 20 solid cancer entities, including CRC, with meta-analyses to solid cancers, hepatocellular cancer, and gastrointestinal tract cancers, such as CRC and gastric cancer [7,8,9,10,11,12].