MACC1 and colorectal carcinoma: The low MACC1 expression was also associated with high CpG island methylator phenotype (CIMP-H), predominantly observed in MSI tumors [32], compared to CIMP-low (CIMP-L) or non-CIMP (median: CIMP-H = 10.18, CRC CIMP-L = 10.54, non-CIMP = 10.77; Wilcoxon test: p = 0.0035 and p = 0.0046, respectively) (Figure S4B).