MACC1 and neoplasm: In this cohort, high MACC1 expression was associated with higher tumor stages (median: stage I–II = 10.45, stage III–IV = 10.62, Wilcoxon test: p = 0.013) (Figure 2C) and nodal invasion (median: N0 = 10.49; N1 = 10.62, Wilcoxon test: p = 0.03) (Figure 2D), association with metastatic status was only modest (median: M0 = 10.54, M1 = 10.77, Wilcoxon test: p = 0.26) (Figure 2E).