In addition, the MACC1 and c-Myc relationship was further substantiated showing a c-Myc increase by MACC1 overexpression in CRC [45], a correlation of MACC1/c-Myc expression in endometrial carcinoma [49], and binding of miR-384 and miR-145-3p miRNAs to MACC1-AS1 thereby altering cell growth phenotype through increased expression of c-Myc mRNAs and PTN (pleitrophin, secreted heparin-binding growth factor [50]). Here, PTN is linked to colorectal carcinoma.