In summary, we showed here that tumors with high MACC1 expression and increased SCNAs were mostly seen in CIN tumors of the CMS2 subtype, which is the epithelial type with marked WNT activation, and of the CMS4 subtype defined as mesenchymal with prominent transforming growth factor activation, stroma invasion and angiogenesis. Here, MACC1 is linked to cervical squamous intraepithelial neoplasia.