MACC1 and neoplasm: High MACC1 expression in tumor samples was further confirmed with a derived dataset reported by Wang et al., 2018 [27] in which COAD-READ tumors were unified with 729 normal tissues from the GTEx database (https://gtextportal.org/home/, accessed on 08 May 2018) (median: COAD tumors = 6.7, and GTEx normal colons = 3.65; READ tumors = 7.14, GTEx normal rectums = 3.52, Wilcoxon test: both p < 2.2 × 10−16) (Figure S3A).