A CA125 level of ≥114.5 U/mL (HR, 1.57; 95% CI, 1.03–2.40), advanced-stage OCCC (HR, 3.21; 95% CI, 1.98–5.22), and poor chemo-response (HR, 4.56; 95% CI, 2.88–7.23) were identified as independent predictors of the risk of cancer progression. The gene discussed is MUC16; the disease is cancer.