Consistent with previous reports [16,17,18], we found markedly higher levels of Enolase 2 in AR-null and significantly higher levels of phospho-S6 ribosomal protein, β-catenin, E-cadherin, and phospho-HSP27 in AR-positive LuCaP PDX tumors (Figure 2), validating that LuCaP samples represent a physiologically relevant model system to interrogate various subtypes of PC. This evidence concerns the gene RPS6 and pachyonychia congenita.