We could demonstrate that (a) EBV+GCs and MMRdGCs show a higher degree of TILs, in particularly close peritumoral/intraepithelial CD8+ lymphocytes; these tumors also more frequently showed a positive PD-L1 status, as determined by a CPS ≥ 1; (b) PD-L1 status correlated in general with higher immune infiltrates and a closer spatial relationship of the immune cells and the cancer cells; and (c) a significant subset of EBV-MMRpGCs showed PD-L1 positivity and/or high peritumoral/intraepithelial CD8+ lymphocytes. Here, CD274 is linked to cancer.